Doctors have long known that fatty food leads to diabetes. However, until recently it was a mystery how it happens.
The research team, led by Jim Marti from the Medical Research Institute Senford-Bern discovered a mechanism that explains the relationship of fatty foods and diabetes, according to The Daily Mail.
As it turned out, fatty foods affect the genetic trigger, which may provoke the development of diabetes. The study of this biological mechanism provides the ability to find new methods for the treatment of severe chronic diseases. To analyze the connection of fatty foods and diabetes test were made using humans and mice. Researchers have found that high levels of fats destroys two key proteins that activate and deactivate genes.
These are transcription factors FOXA2 and HNF1A. They activate the pancreas enzyme (pancreatic) that prevents diabetes. When the protein stops working the enzyme stops working also. This reduces the number of beta cells that produce insulin and leads to increased blood sugar levels. Without this mechanism it is impossible to regulate glucose levels.
Scientists suggest the use of gene therapy, which affects the beta cells or the use of drugs affecting factors FOXA2 and HNF1A. Therefore maintaining enzyme function blocks the formation of diabetes, which was confirmed with obese mice.
Source : The Daily Mail
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